Cancer and Paternal Age?

Many gene mutations drive Cancer

elizabethcharlotte — Fri, 13 Apr 2007 05:13:41 +0000

Many gene mutations drive cancer

Kinase proteins control cell division

The number of mutated genes that drive the development of cancer is greater than had been thought, research shows.However, as well as these “driver” mutations, each type of cancer cell carries many more “passenger” mutations which play no role in causing disease.

The findings, published in Nature, come from the most extensive analysis yet of the human genome and cancer.

Sanger Institute scientists looked at more than 500 human genes and 200 types of cancer.

http://news.bbc.co.uk/2/hi/health/6424117.stm

Paternal age at birth and risk of cancer October 31, 2005 BMC

elizabethcharlotte — Fri, 13 Apr 2007 05:13:11 +0000

BMC Cancer. 2005; 5: 143.

Published online 2005 October 31. doi: 10.1186/1471-2407-5-143.

Association of paternal age at birth and the risk of breast cancer in offspring: a case control study

Ji-Yeob Choi,¹ Kyoung-Mu Lee,¹ Sue Kyung Park,¹ Dong-Young Noh,² Sei-Hyun Ahn,³ Keun-Young Yoo,¹ and Daehee Kang^1,⁴

¹Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon-Dong Chongno-Gu, Seoul 110-799 Korea

²Department of General Surgery, Seoul National University College of Medicine, 28 Yongon-Dong Chongno-Gu, Seoul 110-799 Korea

³Department of General Surgery, Ulsan University College of Medicine, 388-1 Pungnap-2dong Songpa-gu, Seoul 138-736, Korea

⁴Cancer Research Institute, Seoul National University College of Medicine, 28 Yongon-Dong Chongno-Gu, Seoul 110-799 Korea

Corresponding author.

Ji-Yeob Choi: miso77@snu.ac.kr

Kinase proteins control cell division

The findings, published in Nature, come from the most extensive analysis yet of the human genome and cancer.

Sanger Institute scientists looked at more than 500 human genes and 200 types of cancer

http://news.bbc.co.uk/2/hi/health/6424117.stm

Are there associations between advancing paternal age and risk of cancers in offspring?

elizabethcharlotte — Thu, 08 Mar 2007 20:57:11 +0000

- Average paternal age in the UK is increasing. The public healthimplications of this trend have not been widely anticipatedor debated. This commentary aims to contribute to such a debate.Accumulated chromosomal aberrations and mutations occurringduring the maturation of male germ cells are thought to be responsiblefor the increased risk of certain conditions with older fathers.Growing evidence shows that the offspring of older fathers havereduced fertility and an increased risk of birth defects, somecancers, and schizophrenia. Adverse health outcomes should beweighed up against advantages for children born to older parents,mindful that these societal advantages are likely to changeover time.

http://press.psprings.co.uk/jech/october/851_ch45179.pdf