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Many gene mutations drive cancer |
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The number of mutated genes that drive the development of cancer is greater than had been thought, research shows.However, as well as these “driver” mutations, each type of cancer cell carries many more “passenger” mutations which play no role in causing disease. The findings, published in Nature, come from the most extensive analysis yet of the human genome and cancer. Sanger Institute scientists looked at more than 500 human genes and 200 types of cancer. |
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Many gene mutations drive Cancer
April 13, 2007 by elizabethcharlotte
Paternal age at birth and risk of cancer October 31, 2005 BMC
April 13, 2007 by elizabethcharlotte|
Published online 2005 October 31. doi: 10.1186/1471-2407-5-143. Copyright © 2005 Choi et al; licensee BioMed Central Ltd. Association of paternal age at birth and the risk of breast cancer in offspring: a case control study Ji-Yeob Choi,1 Kyoung-Mu Lee,1 Sue Kyung Park,1 Dong-Young Noh,2 Sei-Hyun Ahn,3 Keun-Young Yoo,1 and Daehee Kang 1Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon-Dong Chongno-Gu, Seoul 110-799 Korea 2Department of General Surgery, Seoul National University College of Medicine, 28 Yongon-Dong Chongno-Gu, Seoul 110-799 Korea 3Department of General Surgery, Ulsan University College of Medicine, 388-1 Pungnap-2dong Songpa-gu, Seoul 138-736, Korea 4Cancer Research Institute, Seoul National University College of Medicine, 28 Yongon-Dong Chongno-Gu, Seoul 110-799 Korea
Ji-Yeob Choi: miso77@snu.ac.kr
The number of mutated genes that drive the development of cancer is greater than had been thought, research shows.However, as well as these “driver” mutations, each type of cancer cell carries many more “passenger” mutations which play no role in causing disease. The findings, published in Nature, come from the most extensive analysis yet of the human genome and cancer. Sanger Institute scientists looked at more than 500 human genes and 200 types of cancer |
1,4Are there associations between advancing paternal age and risk of cancers in offspring?
March 8, 2007 by elizabethcharlotte-
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Average paternal age in the UK is increasing. The public health implications of this trend have not been widely anticipated or debated. This commentary aims to contribute to such a debate. Accumulated chromosomal aberrations and mutations occurring during the maturation of male germ cells are thought to be responsible for the increased risk of certain conditions with older fathers. Growing evidence shows that the offspring of older fathers have reduced fertility and an increased risk of birth defects, some cancers, and schizophrenia. Adverse health outcomes should be weighed up against advantages for children born to older parents, mindful that these societal advantages are likely to change over time.
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